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Rodents treated with KD, exogenous -HB, or medium-chain triglycerides (MCTs) showed reduced brain A levels, protection against A toxicity, and improved mitochondrial function [100, 101]

Although mouse and human XDH has some functional similarities, species differences in base/amino acid sequences and protein spatial conformation mean that innovative, highly selective small molecule inhibitors or small nucleic acid drugs designed against human XDH often face "acclimatization" issues in wild-type mice, resulting in significantly compromised binding affinity or efficacy

In isolated mitochondria, coenzyme Q 10 can protect membrane proteins and mitochondrial DNA from the oxidative damage that accompanies lipid peroxidation (5)

"At the moment, I give them a drug for three months and if they lose weight, it means I was lucky

The samples were incubated in a humidified chamber at 37 C in the dark for 60 min