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One study proposes that the hypomethylation of the estrogen receptor (ESR) promoter may potentially contribute to the development of progesterone resistance in individuals with endometriosis (66)

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[17] These are key molecules that play a role in redox balance, and protein synthesis

The same corresponds to the effect of age and aging on the brain barrier functions and the related effects of Se and selenoproteins ( Many studies indicate the critical importance of the exact chemical speciation of essential trace elements (Templeton et al., 2000) in determining their biological activity (Michalke et al., 2018)