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Description

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The metabolism of APAP has been well-studied and the distributions of its metabolites in the plasma and urine of humans are well-documented[4, 6, 7], as are the hepatic values in mice and rats[8]

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These changes in protein expression bring about the fragmentation of mitochondria and their accumulation around the nucleus, which might deprive dendrites and axons of mitochondria [318]

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doi: 10.1038/ng.3061 7 HuangXFLiZDe GuzmanERobinsonPGenslerLWardMMet al

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The current research would be beneficial in resolving this clinical dilemma in the future

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