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Meanwhile, brain tissue accumulation was significantly increased (brain concentration at 1 h post-administration was 2.0 times that of unmodified liposomes and 4.62 times that of free drugs) ( 1 / 2 from 1.93 h to 10.21 h, a higher maximum blood drug concentration (Cmax: 4.58 vs

470 DPP is a local mediator of inflammation and IR in adipose and hepatic tissue that interacts with the integral membrane protein, caveolin-1, then impairing the activation of down-stream AKT signaling