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Alternatively, when isotopic labeling is infeasible, unlabeled metabolomics and/or targeted biochemical assays can detect correlative changes in total off-target metabolite levels, while epistasis studies with multiple genetic and/or pharmacological manipulations can allow causal assessment of whether probable metabolic off-targets are required for given physiological or behavioral readouts

This means most people naturally eat less while on treatment

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts

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