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Oxidative Stress and Autoimmune Thyroid Disease Thyroid follicular cells are among the most metabolically active tissues in the human body, generating significant quantities of hydrogen peroxide (H2O2) during thyroxine (T4) and triiodothyronine (T3) synthesis

(II) Despite the intracellular GSH being significantly consumed in the cases stated in this review, it is difficult to completely deplete GSH via these strategies

Blood 134:37143714 Canli , Alanku YB, Grootjans S et al (2016) Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Visible results often appear gradually over several weeks or months depending on the frequency of treatments and the individual metabolism of the patient

doi: 10.1038/leu.2009.76 304 LvMZhuXChenWZhongSHuQMaTet al