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Theres no way to ease yourself into the regimen or slightly decrease your intake if you experience any of the adverse effects sometimes seen in high-dose NAD+ booster studies, like headache, GI upset, and muscle cramps.32 Itd be better to start with a lower dose that would let you titrate up toward that 1,200mg mark, and Neurogans NMN 500 is a good pick for just that