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This can be an important consideration as one could argue that patients taking GLP-1RAs might differ, compared with patients not on these medications, in their likelihood to have seen an eye care clinician. The commentary encouraged others to take a critical look at the designs and database limitations to understand how confounding, bias and chance may explain discrepancies in studies that rely on large databases

Fang Y, Yan C, Zhao Q, Xu J, Liu Z, Gao J, et al

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The manufacturer stores batches at various temperatures for months and years, measuring degradation at every step