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However, the researchers the trial was marked as completed, but in 2016 they cancelled submission of the results never published the results This is a red flag: we dont know if an issue or toxicity was discovered, or if it was simply a business decision

These agents should not be used alone secondary to increases in plasma renin activity, cardiac output, and heart rate and should therefore be used only when -blockers and diuretics are part of the antihypertensive regimen

Blood 92:11911198