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Class B1 G protein-coupled receptors (GPCRs) play a crucial role in regulating physiological functions, particularly glucose homeostasis and mechanism of action in cardiometabolic syndrome

Furthermore, it remains uncertain whether the signature gene expression pattern observed in mouse models truly represents human pathology when comparing expression patterns in human patient samples, and how reversible trained DAM memories are

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Compounds used for in vivo experiments were further purified by size exclusion chromatography using a HiLoad Superdex 200 pg column (GE Healthcare) and further characterised for endotoxin level using the LAL Kinetic-QCL (Lonza) and integrity by LC/MS using an Acquity UPLC system coupled to a Synapt G1 mass spectrometer (Waters)

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