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Key points Under normal physiologic conditions, changes in bloodbrain barrier (BBB) function are largely in response to the changing needs of the central nervous system

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Adipose tissue, insulin resistance and low-grade inflammation: implications for atherogenesis and the cardiovascular harm of estrogen plus progestogen therapy

But if we stay on our current path, these advances will be subsumed by unnecessary costs, new layers of administration, and invented complexityjust like the past two decades of efficiencies were swallowed up