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De-escalation of five-year adjuvant endocrine therapy in patients with estrogen receptor-low positive (immunohistochemistry staining 1%-10%) breast cancer: propensity-matched analysis from a prospectively maintained cohort

Pharmacy benefit managers report 50%-75% adherence at one year

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With tirzepatide, the active ingredient in Zepbound, people lost an average of 15% to 21% of their body weight over 72 weeks

Additionally, in vitro studies with pituitary cells suggest a similar increase in GH release upon exposure to DSIP, albeit with a notable decline at higher concentrations