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This pattern is potentially significant because it suggests that GI tolerability improves substantially after the initial injection, unlike weekly incretins where GI effects tend to recur with each dose escalation

Most reported cases are mild and tend to diminish over time, though healthcare providers should monitor patients for persistent symptoms

however, the multiparametric improvement across glycemic, hemodynamic, inflammatory, and lipid domains provides a biologically plausible explanation for the previously demonstrated 14% reduction in major adverse cardiovascular events (MACE) in the parent trial