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Rats receiving the large capsule showed increased glial proliferation, brain swelling, and angiogenesis, while those receiving small doses showed preservation of a large number of tyrosine hydroxylase-positive fibers and a neuroprotective effect on dopamine neurons, indicating that VEGF at low doses can potentially support PD treatment (Yasuhara and Shingo 2005)

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In transgenic models, it reduced fibril formation by 62% and striatal deposits by 41%, while also improving motor function without eliciting significant immunogenicity