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Both peripheral gut effects and central brainstem modulation likely lower the hiccup reflex threshold, with a pharmacovigilance review finding 25 of 500 adverse reports involved hiccups (5%), and some trials noting hiccups in about 2% of participants

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10.1016/s0140-6736(87)91194-9 76 KruijverF

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GHK-Cu treatment shows altered methylation at specific gene loci potentially explaining sustained effects beyond immediate peptide presence

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