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Secretins form a functional channel with an OM pore that is 58 nm wide, allowing the passage of large cargo molecules such as folded proteins and multimeric protein fibers

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thus, patients using acetaminophen chronically or in large amounts should be monitored closely when receiving glutathione supplementation

Research shows that glutathione plays a critical role in preventing oxidative damage to cells, proteins, and DNA

A drawback of this assay is that the protein of interest is attached to GST, altering its native state