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Back Rehfeld, JF (March 2021) "Cholecystokinin and the hormone concept', Endocrine Connections , 10/3

The TRIUMPH-4 Phase 3 readout in April 2026 extended that to 28.7% at 68 weeks in a population with knee osteoarthritis - a patient group in whom weight loss produces disproportionate benefit on a secondary outcome (pain) the trial measured and reported as a 75.8% reduction on the WOMAC pain index

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Peptide YY (PYY) is produced in the gastrointestinal tract after eating and helps reduce appetite

(2) offering a uniquely broad and integrative scope that connects molecular mechanisms not only to traditional Atherosclerotic Cardiovascular Disease (ASCVD) and heart failure but also extends the discussion to the emerging and clinically important fields of stroke and vascular dementia