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In addition, a defective aquaporin-8 (AQP8) expression in plasma membrane in EIC might be associated with an impairment of the transient osmotic gradients, inducing defective canalicular functional expression of solute transporters together with a reduced canalicular water permeability, and leading to bile secretory dysfunction (Carreras et al., 2007

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Ethosomes specifically possess elevated ethanol concentrations that augment stratum corneum lipid fluidity and vesicle pliability, thus enhancing the transdermal transit of poorly water-soluble pharmaceuticals [295]

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A rise in stress hormones such as cortisol and adrenaline 17