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Discussion Across rodent and cell models, NNMT inhibition acts as a metabolic re-allocator, simultaneously relieving a methyl sink and diverting nicotinamide back to NAD salvage

Many report no serious issues

Bottom line: It flips a metabolic switch to make your body better at using fat as energy and running more efficiently at the cellular level

This enzyme wastes a helpful molecule called nicotinamide (a form of vitamin B3) by turning it into something useless instead of recycling it into NAD+, think of NAD+ as the main battery fuel that powers your cells energy factories (mitochondria)

NNMT inhibition plus a lean diet accelerates weight/fat loss, improves body-composition indices, and normalizes several liver pathologies versus diet alone [3,4]