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Recent systematic reviews and meta-analyses identified the use of very low-calorie diets, providing 500800 kcal per day and often employing artificial liquid formulas to partially or totally replace meals, as the most effective nutritional strategy in promoting weight loss and potential disease remission in people with diabetes [61]

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And thats even with a muscle-building boost from TRT, says Priya Jaisinghani, M.D., an endocrinologist and obesity-medicine expert at NYU Langone Health