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Native IGF-1 binds IGFBP-3, the dominant carrier protein in circulation, with a dissociation constant in the low nanomolar range (Kd approximately 0.1 to 1 nM in most published binding assays)

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External resources PMC - Inotropic effects of retatrutide in isolated human atrial preparations ClinicalTrials.gov - Effect of Retatrutide on Cardiac Function PMC - Contractile effects of retatrutide in isolated mouse atrial preparations AHA Circulation - GLP-1 Receptor Agonists for Cardiovascular Risk Reduction In case I do not see you, good afternoon, good evening, and good night

IGFBP-3 accounts for roughly 75-80% of total serum IGF-1 binding capacity