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Some people report gastrointestinal symptoms such as nausea, abdominal discomfort, or reflux whilst taking Rybelsus, which can occasionally be perceived as chest discomfort

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Notably, pro-inflammatory genes such as Il13, Il5, Csf2 among others were consistently downregulated following melatonin treatment ( Figure 5C )

Shortly after the drug was released, it was aggressively marketed by Novo Nordisk and quickly became popular for its ability to help with weight loss, which was considered an off-label use