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Clinical studies show afamelanotide significantly increases sunlight tolerance, reduces pain from light exposure, and improves quality of life for EPP patients

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While this can be beneficial for its intended therapeutic effects, it also raises the possibility of off-target effects

In the exploration of the known pathways of cell resistance to ferroptosis, the contents of 15-LOX, ACSL4, and LPCAT3 did not differ significantly, indicating that the ferroptosis resistance of M1 macrophages does not rely on traditional pathways

Individual physiology determines how those results appear in real life