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Fatty liver, in which fat is deposited in the liver tissue, is thought to progress to non-alcoholic steatohepatitis and liver cirrhosis (NASH) when the tissue is exposed to certain stimuli such as oxidative stress and inflammatory cytokines

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For the tumour allograft model, Gclc f/f Rosa26 creERT2 MMTV-PYMT mice and control C57BL/6 mice (The Jackson Laboratory, 000664) were used (female, at least 12 weeks old)

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doi: 10.3389/fimmu.2019.01511 191 ZhuHYangHZhaoSZhangJLiuDTianYet al