1.3 The established role of GLP-1 receptor agonists in obesity and T2D Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were originally introduced as therapeutic agents for T2D
De Felice et al., 2012
The best long-term approach is to eat an anti-inflammatory diet, optimize sleep, improve movement and fitness, and manage stress
15 Being a powerful antioxidant, glutathione plays a critical role in several metabolic pathways: DNA and protein synthesis, amino acid transport, enzyme activation, immune system function, scavenging free radicals eg hydrogen peroxide, cofactor in Phase I cytochrome P450 enzyme-mediated detoxification, amino acid translocation across cell membranes, detoxification of xenobiotics, maintenance of sulfhydryl groups of proteins, mitochondrial function and maintenance of mitochondrial DNA, catalysis of exchange reactions and many more
Targeting ferroptosis thus offers a promising avenue for precision oncology in renal cancer, warranting further development of selective inducers and biomarker-guided therapeutic regimens
