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Immune Function and Inflammation: Epitalons Role as a Cytokine Modulator As we age, the immune system undergoes a progressive decline in function, a phenomenon known as immunosenescence

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It is diagnosed according to the Canadian consensus criteria, at least 6 months after onset when the following symptoms are present: fatigue, post-exertional malaise with a recovery period of at least 24 h, sleep dysfunction, pain, at least two neurological/neurocognitive symptoms and at least two symptoms involving the autonomic, neuroendocrine or immune system [19]

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