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So what needs to change

Therefore, following the approval of Exenatide, development of GLP-1 drugs mainly focused on two directions: developing long-acting GLP-1RAs and oral GLP-1RAs (Figure 3)

The American Diabetes Association's Standards of Care recommend GLP-1 receptor agonists as second-line therapy for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or high cardiovascular risk, regardless of baseline HbA1c [1]

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When used together, these side effects might be more noticeable, and there could be new side effects that happen because of the combination