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The science of Sermorelin Clinically studied and naturally acting : Sermorelin is an analog of growth-hormone-releasing hormone (GHRH). Unlike direct HGH therapy, Sermorelin signals the pituitary gland to release human growth hormone (HGH) in a pulsed, physiological rhythm, supporting a more balanced approach to hormone therapy. 6 Why HGH levels matter : Research suggests Sermorelin may help naturally restore growth hormone signaling, supporting your bodys ability to build muscle, restore energy, and improve overall quality of life, among other diverse potential benefits