The clinical significance was highlighted by Lilly's leadership: "Obesity is a chronic, progressive disease, and sustaining weight loss remains a significant challenge for many," said Kenneth Custer , Ph.D., executive vice president and president, Lilly Cardiometabolic Health
However, the SGLT2i treated cohort were less likely to develop heart failure (RR 0.44 [95% CI 0.23, 0.83] p =0.0092), CKD (RR 0.49 [95% CI 0.28, 0.86] p =0.0118) and be hospitalised for any cause (RR 0.59 [95% CI 0.46, 0.76] p 0.0001) when compared with the GLP-1 RA treated cohort
Some readers have told us they find the taste cloying compared to sugar
But while the physical transformations are often celebrated, a new concern is quietly emerging one thats showing up in the skin
Conclusion Feeling tired on GLP-1s is common and in many cases, its a practical mismatch between your new appetite and your old routine