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These effects are largely mediated through activation of Wnt/-catenin, BMP2/Smad/Runx2, PI3K/Akt, MAPK, and GLP-1Rdependent cascades, supporting their potential as multifunctional modulators in regenerative medicine (Fig

In August last year, Williams said she was taking a weight-loss medication, Zepbound, after struggling to shed kilograms through dieting and exercise after her two pregnancies

It acts as a melanocortin MC3/MC4 receptor agonist

So, pharmaceutical companies started investigating the use of GLP-1s for weight-management purposes, and the first GLP-1 weight-loss drug, Saxenda (liraglutide), was approved by FDA in 2014 (it was previously approved to treat diabetes under the name Victoza)

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