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How GLP-1 medications work in different body systems Heres how GLP-1 hormones and receptors function in different organ systems: In the brain , GLP-1 receptors in the hypothalamusthe part of the brain responsible for appetite and thirsttell us we can stop eating In the muscles , GLP-1 kickstarts your gluconeogenesis process: The conversion of protein and fats into the glucose (sugar) that fuels your muscles In the stomach , GLP-1 slows down the rate at which food is digested and is cleared from the stomach

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