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Therapeutic Applications of DPP-4 Inhibitors: 5.1 Treatment of Type 2 Diabetes Mellitus (T2DM) 5.1.1

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Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress

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This acylation is what gives it its extended half-life of approximately six days, allowing for once-weekly dosing