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Some patients may stay on GLP-1 medication forever, others may only rely on it for 6 to 12 months

Lim WS, Ng DL, Kor SB, Wong HK, Tengku-Muhammad TS, Choo QC, Chew CH (2013) Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPAR) in human hepatocarcinoma HepG2 cells by activation of NF-B pathway

This dual activity is why Tirzepatide will help control hunger, control blood sugar and thus increase weight loss faster than many other weight loss medications

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The GLP-1R agonists are promising candidates for the treatment of obesity