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While the 2024 guidelines already recommended glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss due to their proven efficacy in reducing body weight and improving glycemic control, the 2025 update broadens their scope of use for their multifaceted benefits in diabetes management, including weight loss, kidney disease, and metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic-associated steatohepatitis (MASH) [11, 12]

Morgan, the total number of GLP-1 users in the U.S

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Wegovy is the best-known semaglutide brand for weight loss