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Vegans and vegetarians are naturally at higher risk since B12 comes mainly from animal products

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Interestingly, animals like salamanders and axolotl are able to regenerate entire limbs, and this regenerative process is driven primarily by hematopoietic and myeloid stem cells, which in the human is the equivalent of bone marrow stem cells that drive mesenchymal cell lineages of ligament, cartilage, muscle, bone, and connective tissues [52]

Another emerging strategy is the production of synbiotics, i.e., the combination of prebiotics and probiotics, such as Bifidobacterium lactis plus fructo-oligosaccharides, which appear to offer a positive contribution in improving intestinal function and decreasing pro-inflammatory cytokines levels, more than the individual elements [73]