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SUSTAIN-6 (semaglutide) [53], PIONEER 6 (semaglutide) [61], and LEADER (liraglutide) [54] looked at similar patient populations (over 50 years old with established cardiovascular disease) and found that GLP-1RAs produce a cardiovascular protective function relative to primary endpoints (Table 1)

Headache disorders may be a risk factor for the development of new onset hypothyroidism

Injections typically produce faster satiety effects and allow providers to adjust doses more precisely than oral tablets

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None of these interactions are absolute contraindicationsrather, they require informed prescriber assessment and potential dosing or timing adjustments