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In a 12-month study of healthy older adults, MK-677 increased fat-free mass by about 1.6 kg compared with placebo , although it did not clearly improve strength or functional performance

Studies on the intestinal microbiota have shown an inverse relationship between microbiota diversity and neurological disorders, a reduction in Bacteroidetes , and reduced expression of TJ proteins in the intestinal mucosa [95, 113,114,115]

Still, it requires careful consideration and planning to ensure the process is safe and effective for each patient

Nature Medicine, 28(3), 591-598