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South Florida patients dealing with metabolic syndrome, post-menopausal body composition shifts, or age-related GH decline are increasingly combining tesamorelin with other protocols for a comprehensive approach

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Possible explanations for how HRT could adversely affect MASLD development include adverse effects from the progesterone component of HRT (which is infrequently considered in existing studies), nonphysiologically high hepatic estrogen exposure from oral estrogens, and the inability to replicate the natural oscillatory patterns of hepatic estrogen exposure in the premenopausal state (10)