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Although this class of drugs has been FDA-approved and used to treat type 2 diabetes since 2005, their use as a treatment for obesity and the explosion in public awareness that followed has been a more recent development

Type 2 diabetes mellitus (DM2) affects a 13.8% of the Spanish population1 and its prevalence is expected to increase in the future.2 The presence of DM2 increases significantly the risk of cardiovascular events, chronic kidney disease (CKD), and premature death3,4 and as its prevalence increases it is expected to rise the incidence of microvascular and macrovascular complications.5 Until the last decade, the control of blood glucose, blood pressure, dyslipidemia, and the use of inhibitors of the renin-angiotensin system (iSRA) have been the only strategies available to reduce cardiovascular and renal risk in this population

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Open J Obstetrics Gynecol (2022) 12(1):5666

no serious adverse events reported in long-term studies [5]