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Unlike GLP-1 agonists, the changes are compositional rather than scale-weight driven: patients may not lose significant total body weight but will show meaningful reduction in waist circumference and visceral fat volume

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MOTS-c: the mitochondrial peptide with bone-protective effects MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide discovered in 2015