As always, it is advisable to consult with a healthcare professional before starting any new peptide therapy or supplementation regimen.
If someone has a less efficient MTHFR variant, there would be less methylfolate, and therefore less methylcobalamin for converting homocysteine
10.1016/j.brainresbull.2018.08.021 Brain Res
Further studies have shown that HFD can reduce the expression of GLP-1 receptors in the liver, while supplementation with butyrate, a GLP-1 sensitizer, upregulates the levels of GLP-1 receptors in the liver, which stimulates AMPK phosphorylation (69)
While these are smaller single studies, taken together these articles identify possible new tools in an overall assessment, and highlight the benefits of using functional nutrition and lifestyle medicine