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This is the amplification of pain transmission along the entire pain neuraxis, from peripheral nociceptors to the upper CNS regions that form the pain matrix and encode the perceptive, cognitive, and emotional aspects of pain [164]

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Type 2 diabetes Obesity (an IRS-recognized chronic medical condition) Cardiovascular disease Hypertension Fatty liver disease (MASLD/NASH) Chronic kidney disease Generally NOT deductible if used for

Retatrutide (LY3437943) is the next-generation candidate in this class

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