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A simpler surrogate is the acetaminophen (paracetamol) absorption test : because acetaminophen is negligibly absorbed by the stomach but rapidly absorbed by the small intestine, the rise in its plasma concentration tracks the rate of gastric emptying a convenient method often embedded in early-phase metabolic studies

doi: 10.1016/j.abb.2003.08.036 17 SlominskiAPisarchikASemakISweatmanTSzczesniewskiAWortsmanJ

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Engages dopaminergic and serotonergic systems in rodent CNS injury models

By controlling the abundance and activity of various cellular proteins, the UPP directly influences signal transduction pathways and gene expression