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These side effects are generally mild, but in some cases, people may experience more serious issues, such as low blood sugar (hypoglycemia) if they take other diabetes medications with semaglutide

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Theres a fundamental distinction between naturally produced GLP-1 and GLP-1 receptor agonist (GLP-1a) drugs: GLP-1 Agonists (Drugs): These are chemically modified versions of GLP-1 that are more resistant to degradation, giving them a longer half-life

This finding may also be related to the effect of GLP-1RA on the Erk1/2 signaling pathway (97)