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As a small molecule weighing approximately 529 Da, orforglipron binds to an allosteric pocket within the transmembrane domain of the GLP-1 receptor, stabilizing the active receptor conformation and driving downstream signaling through Gs protein coupling and cAMP accumulation

performed a population-based cohort study in Taiwan employing a target trial emulation design to reduce confounding in 97,628 patients with type 2 diabetes [57]

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