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doi: 10.1111/nyas.12798

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This effect is believed to occur through PYY(136) binding to Y1 receptors in the hypothalamus, which activates NPY/AgRP neurons, increases NPY expression in the ARC, and indirectly inhibits pro-opiomelanocortin/Cocaine amphetamine regulated transcript (POMC/CART) neurons [47, 49]