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However, limited representation of lean MASH and certain ethnic groups (e.g., Black patients) constrains generalizability to those subpopulations, an issue shared by many MASH trials [1]

Because most plasma GSH originates in hepatocytes, the authors hypothesized that decreased plasma GSH also could signify intracellular depletion

As we discussed in section III.C.2.e of this final rule, we have designed the complex patient and small practice scoring adjustments so that we would help offset the challenges commonly faced by these practice types

This changes the peptide's shape and function