Another 2025 survey published in JAMA Health Forum noted that, should Medicare pay for the drugs, it could avoid spending a hypothetical $18.2 billion on obesity-related health expenditures over 10 years while dishing out $65.9 billion annually on the GLP-1s by year 10, thereby negating any savings
Currently approved delivery methods include: Subcutaneous injection : The most common route, using pre-filled pens for once-weekly (semaglutide, dulaglutide) or once-daily (liraglutide) administration Oral tablets : Semaglutide (Rybelsus) is the only FDA-approved oral GLP-1 medication, utilizing absorption-enhancing technology No transdermal patch formulation has received FDA approval for GLP-1 delivery
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One consequence of this popularity is that despite their high cost, the GLP-1 agonist medications have seen demand outstrip their supply resulting in shortages making their availability to treat diabetes more limited
We faced persistent opposition from some members of Congress, who were concerned about the laws economic impact on small pharmacies
