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If the decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe the lowest effective dosages and minimum durations of concomitant use

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158 Available findings have allowed us to speculate that the biological activities of oxidized AAT may depend on the magnitude of AAT oxidation, in a manner similar to that discussed for HSA (Figure 3)