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doi:10.1210/jc.2007-0606
doi: 10.1126/science.1241214 107 van NoodEVriezeANieuwdorpMFuentesSZoetendalEGde VosWMet al
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We cross-referenced the downregulated metabolite induced by TS compared to that of the CON group and the upregulated metabolite induced by GABA treatment compared to that of the TS group and observed that 15 metabolites were significantly upregulated after GABA treatment
Although the development of specific IRE1 activators remains primarily at a preclinical stage, a promising cancer therapeutic approach would be to utilize small molecule IRE1 activators to induce ferroptosis selectively in tumors or to restore ferroptosis in tumors that have developed resistance to this mechanism of cell death
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